HEPATOPROTECTIVE AND ANTIDIABITIC EFFECTS OF  AQUEOUS Moringa oleifera LEAVES EXTRACT ON EXPERIMENTAL RATS

Ghoneim, Gehan; Ibrahim, Faten; El-gammal, Rania

doi:10.21608/jpd.2016.42267

HEPATOPROTECTIVE AND ANTIDIABITIC EFFECTS OF AQUEOUS Moringa oleifera LEAVES EXTRACT ON EXPERIMENTAL RATS

Document Type : Original Article

Authors

Food Industries Department, Faculty of Agriculture, Mansoura University, 35516, Mansoura, Egypt.

10.21608/jpd.2016.42267

Abstract

This study was designed to determine the total phenols , flavonoids and antioxidative effect of aqueous Moringa oleifera Leaves extract (AMLE) on the biochemical profile of hepatic dysfunction and diabetic male rats. It was found that AMLE contained 698.82 mg/g of total phenolic compounds , 26.33 mg/g of total flavonoids and antioxidant activity (DPPH) recorded 81.6%. Also, the results indicated that e-vanillic acid (1988.32 ppm) and syringic acid (898.25ppm)were the dominant phenolic compounds in AMLE.
Concerning the biological assay, the obtained results showed that there were significant differences between only Lipopolysaccharides (LPS) treated group and those treated with LPS followed by AMLE or AMLE followed by LPS. Where, it could be noticed that there were significant decreases in all liver function values except for serum albumin,which increased and reached to 4.00 mg/dl in treated group with AMLE followed by LPS. In addition , AMLE improve kidney functions.
Also, antioxidant enzyme concentrations (SOD) increased in treated group with AMLE group followed by treated group with LPS and reached 30.33 U/L. On the other, hand the treatment with AMLE decreased LDL-cholesterol and increased HDL-cholesterol levels at the end of experimental period compared with those of LPS treated group .
As biochemical indices, it could be noticed that blood glucose recorded an improvement in group treated with amaryl drug (167.66 mg/dL) and AMLE group (180.66 mg/dL) compared with Streptozotocin (STZ ) group (306.66 mg/dL).
Conclusively, it briefly could concluded that aqueous Moringa olifieria leaves extract had vital effects to prevent LPS induced hepatic dysfunction and gluscose blood level by its high content of polyphenols.

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