FFOREHEAD BOX PROTEIN P3 POLYMORPHISM AS A RISK FACTOR OF PREECLAMPSIA: SEVERITY ASSOCIATION

Hasan, Mohammad; Abd Elkader, Hadeer X; Nasr, Mohamed Younis; Mansour, Amal; Osman, Mohamed

doi:10.21608/jpd.2022.246079

FFOREHEAD BOX PROTEIN P3 POLYMORPHISM AS A RISK FACTOR OF PREECLAMPSIA: SEVERITY ASSOCIATION

Document Type : Original Article

Authors

¹ Bioinformatics Department, Genetic Engineering and Biotechnology Research Institute (GEBRI). University of Sadat City, Egypt. University of Sadat City, Egypt.

² Department. of Molecular Biology, Genetic Engineering and Biotechnology Research Institute (GEBRI). University of Sadat City, Egypt.

³ Department. of Molecular Biology, Genetic Engineering and Biotechnology Research Institute (GEBRI). University of Sadat City, Egypt

⁴ Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine,Ain Shams University, Egypt.

⁵ Bioinformatics Department, Genetic Engineering and Biotechnology Research Institute (GEBRI). University of Sadat City, Egypt

10.21608/jpd.2022.246079

Abstract

Pre-eclampsia is a major cause of maternal and fetal mortality and morbidity. The incidence of pre-eclampsia is 2-10%, depending on the population studied and definitions of pre-eclampsia. Significantly more infants were delivered before the onset of labour and by caesarean section in the group with pre-eclampsia. This study aimed to investigate the association of studied groups with albuminuria, BMI, blood pressure, gestational age, baby wt, age, placental wt, mode of delivery, abortion, fox p3 polymorphism and genotype. Total 75 (25 normotensive women as a control group, 25 women with mild preeclampsia, 25 women with severe preeclampsia) women were enrolled in this study. The anthropometric measurements and clinical characteristics of different study groups as age(18-40), BMI(21-35), diastolic blood pressure(70-150), systolic blood pressure(100-200),abortion(0,1,2),placental wt(300-480),baby wt (2200-3800), albumin (0,1,2,3),mode of delivery (Normal & cs), genotype (GG,TT,TG), gestational age (35-41), and result was analyzed. Placenta samples were collected from the patients attended the Obstetrics and Gynaecology clinic, and informed consents will be obtained from all of them. Age and BMI were taken for each participant.
The most important characteristic of Tregs is their expression of the transcription factor FOXP3. Participants with heterozygous (TG) and homozygous (TT) genotypes had higher BMI compared to those with wild-type (GG, TT, TG) genotypes. Therefore, The women with GG and TG genotypes were severe PE than TT ones and all these associations were statistically significant (P<0.05). Participants with heterozygous (TG) and homozygous (TT) genotypes had higher BMI compared to those with wild-type (GG) genotypes. Women with a history of abortion who conceived again with the same partner had nearly half the risk of preeclampsia. In Conclusion, Increasing BMI is associated with increased risks of adverse obstetric outcomes.
Conclusively, the protective effect of a prior abortion operated only among women who conceived again with the same partner. An immune-based etiologic mechanism is proposed, whereby prolonged exposure to fetal antigens from a previous pregnancy protects against preeclampsia in a subsequent pregnancy with the same father.

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