COMPARISON BETWEEN PICSI AND ICSI AND ITS EFFECT ON BLASTOCYST FORMATION, A PROSPECTIVE RANDOMIZED TRIAL.

Document Type : Original Article

Authors

1 Department of Animal Biotechnology, Genetic Engineering and Biotechnology Research Institute, University of Sadat City, Sadat City, Egypt

2 Department of Obstetrics and Gynecology, Faculty of Medicine, Assuit University, Egypt.

3 Department of Animal Biotechnology, Genetic Engineering and Biotechnology Research Institute, University of Sadat City, Sadat City, Egypt.

Abstract

Although ICSI may not provide a significant advantage over in vitro fertilization (IVF) in cases of non-male factor infertility, it is recommended to for search another method to increase the baby take-home rate in Assisted Technology. To assess the efficacy of two ready-to-use systems: intracytoplasmic sperm injection (ICSI) and Physiological intracytoplasmic sperm injection (PICSI) in a randomized manner on embryo development and blastocyst formation. This study was designed as a prospective, randomized trial. Couples receiving an ICSI or PICSI treatments with fresh embryo transfer were enrolled in this parallel two-groups, randomized trial. The study included 100 infertile women. Their age was between 25 to 39 years. Freshly ejaculated sperms for the treatment after at least 3 days of sexual abstinence. Couples were randomly randomized (1:1) to receive either PICSI or a standard ICSI procedure.PICSI and ICSI showed no statistically significant difference as regards fertilization rate, implantation rate and embryo transfer rate but showed statistically significant in blastocyst formation, clinical pregnancy and pregnancy continuation.
Conclusively, according to these findings, the PICSI technique had a higher chance of achieving pregnancy than the ICSI technique.As a result, the approach is preferable to be used in laboratory routine work than ICSI to avoid the selection of immature sperm, which leads to increased clinical pregnancy in male factor infertility, especially with DNA fragmentation. To back up this claim, prospective and randomized trials should be used.
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